Incorporating the most important advances in the rapidly-evolving field of cancer biology, this book remains the defining course text on its subject. Students, instructors, researchers, and clinicians the world over admire its authoritative content, clear explanations, extensive full-color art program, and pedagogical features that promote a deep conceptual understanding of the science through the lens of fascinating tales of scientific discovery.

CONTENTS

1. The Biology and Genetics of Cells and Organisms

2. The Nature of Cancer

3. Cancer as an Infectious Disease

4. Cellular Oncogenes

5. Growth Factors, Receptors, and Cancer

6. Cytoplasmic Signaling Circuitry Programs Many of the Traits of Cancer 

7. Tumor Suppressor Genes

8. pRB and Control of Cell Cycle Clock

9. p53: Master Guardian and Executioner

10. Eternal Life: Cell Immortalization and Tumorigenesis

11. Multi-step Tumorigenesis

12. Shaping and Characterizing the Cancer Genome

13. Dialogue Replaces Monologue: Heterotypic Interactions and the Biology of Angiogenesis

14. Moving Out: Invasion and Metastasis

15. Crowd Control: Tumor Immunology

16. Cancer Immunotherapy

17. The Rational Treatment of Cancer